MINOXIDIL BOOST BY RIDA HAIR RESEARCH INSTITUTE
Jane Dow, PhD in Cellular Biology, explains the benefits of Minoxidil Boost, a clinically-proven hair regrowth enzyme boosting system.
What is Minoxidil Boost?
The Minoxidil Boost System is an innovative formula designed for both men and women. With its unique, patent-pending, nanosome delivery system for maximum penetration, it is a breakthrough boosting agent, comprising a complex of several powerful ingredients:
• SULT1A1(minoxidil sulfotransferase)• Retinoic Acid
• Arginine
• Copper peptides
• Biotin
• Proharin-B4
• Lecitin
• Proprietary Nanosome Delivery System
How does it work?
Topical Minoxidil is the most common treatment for Androgenetic Alopecia (AGA) in both men and women. Although topical Minoxidil exhibits a good safety profile, the efficacy in the overall population remains relatively low at 30–40%. Active ingredients of the Minoxidil Boost work in conjunction with a Minoxidil daily routine to provide the following benefits:
• Enriches natural hair sulfotransferase enzymes to promote healthy growth
• Improves hair density and thickness resulting in visibly fuller, more luscious hair
• Optimizes follicular and hair health
• Active ingredients deliver improved condition of both hair and scalp
Science behind Minoxidil Boost:
The efficacy of Minoxidil relies on certain enzymatic activity in the scalp. Sulfotransferase enzymes found in the outer root sheath of the hair follicles are responsible for converting Minoxidil to Minoxidil sulfate, the pro-drug’s active form. In particular, endogenous sulfotransferase 1A1 (SULT1A1) is the dominant isoform of the enzyme that plays a key role in the conversion of minoxidil. The correlation between SULT1A1 expression in the scalp and minoxidil response has been previously reported. Clinical studies have shown that 75% of subjects treated with the SULT1A1 adjuvant responded to minoxidil treatment after 60 days of use.
Retinoic Acid strengthens the scalp by boosting collagen production and improving cell turnover to create optimal conditions for hair growth. When used in combination with minoxidil, results have proven it to have a positive effect on hair follicle growth and the proliferation of dermal papilla cells and epidermal keratinocytes. Of clinical significance, about 50% of patients with Androgenic Alopecia, initially predicted to be non-responders to Minoxidil, showed a positive response following topical Retinoic Acid application.
Arginine is an amino acid that acts as the physiological precursor for nitric oxide (NO) synthesis in animal cells. NO is s pre-requisite for the stimulation of hair growth, acting as a vasodilator, and plays a role in the opening of potassium channels, essential for the functional mechanism of Minoxidil.
Copper Peptides and Biotin are proven to act as a growth factor in cell differentiation. In addition they are responsible for stimulating keratin production, proliferation of human dermal fibroblasts and increasing the production of vascular endothelial growth factor.
Lecitin together with other key ingredients, assist in the proprietary nanosome delivery system to achieve a better penetration of this formula to the cells for maximum results.
Clinically Proven:
A 60-day clinical trial was performed to assess the efficacy of the Minoxidil Boost to increase the response rate of patients using Minoxidil. A cohort of fifty-four females and eighty-two males with Androgenic Alopecia were recruited as part of a randomized, blinded, placebo-controlled study. Half of the patients were randomized to the active treatment and half to the placebo.
Of the group using Minoxidil plus placebo, 15 out of 41 (36%) male subjects and 10 out of 27 (37%) female subjects showed a positive increase in hair growth and thickness. Of the group using Minoxidil plus Minoxidil Boost, 33 out of 41 (80%) male subjects and 21 out of 27 (78%) female subjects had a positive increase in hair growth and thickness. Future studies are currently underway to further elucidate the benefits of Minoxidil Boost as adjuvant therapy for Minoxidil users.
References:
1) Ramos PM, et al. J. European Academy of Dermatology and Venereology 2021; Jan;35(1):e24-e262) Buhl AE, et al. J Invest Dermatol 1994; 102: 534.
3) Dhurat R, et al. J Cosmet Dermatol. doi:10.1111/jocd.14299
4) Kwon OS, et al. Journal of Korean Medical Science 2007; 22(2): 283-289.
5) Sharma A, et al. Dermatol Ther. 2019 May;32(3):e12915.
6) Uno H, Kurata S. J Invest Dermatol. 1993 Jul;101(1 Suppl):143S-147S.
7) Marotta JC, et al. Int J Pharm Comp 2020 Jan-Feb; 24(1):69-76
8) Garre A et al., J Cosmo Trichol 2018, 4:1
9) Yazdani-Arazi SN, et al. Artif Cells Nanomed Biotechnol. 2017 Nov;45(7):1379-1387.
10) Uprit S, et al. Saudi Pharm J. 2013 Oct;21(4):379-85.
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